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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11306073 B1

PDFFull Text
Date of Patent:
Apr. 19, 2022

Filed:

Dec. 22, 2016

N-acylurea derivative and composition comprising same for prevention or treatment of cardiovascular disease

Applicants:

Korea University Research and Business Foundation, Seoul, KR;

Kyungpook National University Industry-academic Cooperation Foundation, Daegu, KR;

Inventors:

Soon Jun Hong, Seoul, KR;

Chung Ho Kim, Gyeonggi-do, KR;

Hyung Joon Joo, Seoul, KR;

Jong-Ho Kim, Seoul, KR;

Ji-Young Park, Seoul, KR;

Seung Cheol Choi, Seoul, KR;

Chan-Sik Yang, Seoul, KR;

Jong Hwa Jung, Daegu, KR;

Minseon Jeong, Gyeongsangbuk-do, KR;

Miseon Ryu, Gyeongsangnam-do, KR;

Sugyeong Kwon, Daegu, KR;

Assignees:

KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, Daegu, KR;

KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERTION FOUNDATION, Daegu, KR;

Attorneys:

Hultquist, PLLC

Steven J. Hultquist

Primary Examiner:

Amanda L Aguirre

Int. Cl.
CPC ...
A61P 9/10 (2006.01); A61P 9/12 (2006.01); C07C 275/30 (2006.01); C07C 275/50 (2006.01); C07D 209/08 (2006.01); C07D 209/14 (2006.01); C07D 213/61 (2006.01); C07D 213/75 (2006.01); C07D 257/04 (2006.01); C07D 265/30 (2006.01); C07D 295/10 (2006.01); C07D 295/104 (2006.01); C07D 295/185 (2006.01); C07D 317/64 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); A61K 47/02 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 9/0019 (2013.01); A61K 9/145 (2013.01); A61K 9/2018 (2013.01); A61K 9/4866 (2013.01); A61K 47/02 (2013.01); C07C 275/30 (2013.01); C07C 275/50 (2013.01); C07D 209/08 (2013.01); C07D 209/14 (2013.01); C07D 213/61 (2013.01); C07D 213/75 (2013.01); C07D 257/04 (2013.01); C07D 265/30 (2013.01); C07D 295/10 (2013.01); C07D 295/104 (2013.01); C07D 295/185 (2013.01); C07D 317/64 (2013.01); C07D 403/12 (2013.01); A61P 9/10 (2018.01); A61P 9/12 (2018.01);
Abstract

The present invention relates to a novel N-acylurea derivative and the use thereof for the prevention or treatment of cardiovascular disease, and more particularly to a novel N-acylurea derivative, a pharmaceutical composition for prevention or treatment of cardiovascular disease, which contains the N-acylurea derivative as an active ingredient, and a method of preparing the N-acylurea derivative. The N-acylurea derivative according to the present invention can inhibit platelet aggregation by inhibiting the activity of talin in the intracellular matrix, and thus can be useful for the prevention or treatment of cardiovascular disease.

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