The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Oct. 07, 2019
Applicant:
Edwards Lifesciences Corporation, Irvine, CA (US);
Inventors:
James A. Davidson, San Juan Capistrano, CA (US);
Jeffrey S. Dove, Santa Ana, CA (US);
Darin P. Dobler, Aliso Viejo, CA (US);
Assignee:
Edwards Lifesciences Corporation, Irvine, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61F 2/24 (2006.01); A61L 27/50 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3625 (2013.01); A61F 2/2412 (2013.01); A61L 27/3683 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); A61L 27/507 (2013.01); A61F 2210/0004 (2013.01); A61F 2210/0076 (2013.01); A61L 2400/02 (2013.01); A61L 2430/20 (2013.01); A61L 2430/40 (2013.01);
Abstract
A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant.