The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
May. 18, 2018
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Adrienne Boire, New York, NY (US);
Joan Massague, New York, NY (US);
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/00 (2006.01); A61K 31/7105 (2006.01); A61P 35/04 (2006.01); A61K 31/166 (2006.01); A61K 31/4745 (2006.01); A61K 31/7068 (2006.01); A61K 45/06 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 45/00 (2013.01); A61K 31/166 (2013.01); A61K 31/4745 (2013.01); A61K 31/7068 (2013.01); A61K 31/7105 (2013.01); A61P 35/04 (2018.01); G01N 33/57407 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention relates to methods and compositions for modulating the blood CSF barrier and for diagnosing, preventing and/or treating leptomeningeal metastasis. In particular embodiments of the invention, the permeability of the blood CSF barrier is modulated by agonists or antagonists of Complement Component 3 (C3) or its receptor.