The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2022

Filed:

Aug. 25, 2015
Applicants:

Drexel University, Philadelphia, PA (US);

Thomas Jefferson University, Philadelphia, PA (US);

Inventors:

John Robert Eisenbrey, Philadelphia, PA (US);

Margaret Alison Wheatley, Media, PA (US);

Patrick O'Kane, Philadelphia, PA (US);

Lorenzo Albala, Philadelphia, PA (US);

Flemming Forsberg, Lafayette Hill, PA (US);

Assignees:

Drexel University, Philadelphia, PA (US);

Thomas Jefferson University, Philadelphia, PA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 41/00 (2020.01); A61K 49/22 (2006.01); A61K 33/00 (2006.01); A61K 9/00 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0028 (2013.01); A61K 9/0009 (2013.01); A61K 33/00 (2013.01); A61K 41/0038 (2013.01); A61K 49/223 (2013.01); A61N 2005/1098 (2013.01);
Abstract

The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.


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