The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Jan. 19, 2018
The Research Foundation of the State University of New York, Albany, NY (US);
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Glattpark, CH;
Brookhaven Science Associates, Llc, Upton, NY (US);
Brian A. Crowe, Leobendorf, AT;
Ian Livey, Vienna, AT;
Maria O'Rourke, Wiener Neudorf, AT;
Michael Schwendinger, Neusiedl am See, AT;
John J. Dunn, Bellport, NY (US);
Benjamin J. Luft, Riverhead, NY (US);
Brookhaven Science Associates, LLC, Upton, NY (US);
The Research Foundation of State University of New York, Albany, NY (US);
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta GmbH, Glattpark, CH;
Abstract
The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety ofgenospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.