The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Dec. 18, 2019
Applicant:
Academisch Ziekenhuis Leiden, Leiden, NL;
Inventors:
Assignee:
Academisch Ziekenhuis Leiden, Leiden, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/48 (2006.01); C12N 9/64 (2006.01); C07K 14/46 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4846 (2013.01); C07K 14/46 (2013.01); C12N 9/6432 (2013.01); C12Y 304/21006 (2013.01); C07K 2319/00 (2013.01);
Abstract
This disclosure relates to recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an anti-coagulant effect of a coagulation inhibitor in a subject.