The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
Nov. 16, 2018
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Julien Lefranc, Berlin, DE;
Norbert Schmees, Berlin, DE;
Ulrike Röhn, Berlin, DE;
Ludwig Zorn, Berlin, DE;
Judith Günther, Berlin, DE;
Ilona Gutcher, Berlin, DE;
Lars Röse, Berlin, DE;
Benjamin Bader, Berlin, DE;
Detlef Stöckigt, Potsdam, DE;
Michael Platten, Heidelberg, DE;
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Deutsches Krebsforschungszentrum, Heidelberg, DE;
Abstract
The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R, Rand Rare as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.