The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2022
Filed:
May. 14, 2020
Chang Gung University, Taoyuan, TW;
Chang Gung Memorial Hospital, Linkou, Taoyuan, TW;
Chia-Yu Yang, Taoyuan, TW;
Kai-Ping Chang, Taipei, TW;
Chia-Hsun Hsieh, Taoyuan, TW;
Chih-Ching Wu, Taoyuan, TW;
Chun-Nan Ouyang, Taoyuan, TW;
Chiao-Rou Liu, Taoyuan, TW;
CHANG GUNG UNIVERSITY, Taoyuan, TW;
CHANG GUNG MEMORIAL HOSPITAL, LINKOU, Taoyuan, TW;
Abstract
Provided herein is a method for treating an oral cancer in a subject. According to embodiments of the present disclosure, the method comprises respectively obtaining a first and a second biological samples from a lesion site and a non-lesion site of the subject; respectively measuring the expression levels of CHEK1, PIK3CA, or PIK3CD in both biological samples by qRT-PCR thereby obtaining a first and a second expression level; determining the ratio of the first to the second expression level; and administering to the subject an effective amount of a checkpoint kinase 1 inhibitor when the ratio for CHEK1 is at least 1.7 or a phosphatidylinositol 3-kinase inhibitor when the ratio for PIK3CA is at least 2.4, or when the ratio for PIK3CD is at least 3.1.