The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2022

Filed:

Aug. 21, 2015
Applicants:

Crescendo Bioscience, South San Francisco, CA (US);

Oklahoma Medical Research Foundation, Oklahoma City, OK (US);

Inventors:

Guy L. Cavet, Burlingame, CA (US);

Yijing Shen, San Mateo, CA (US);

Nicholas Knowlton, Choctaw, OK (US);

Michael Centola, Oklahoma City, OK (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/53 (2006.01); G16B 40/00 (2019.01); G16B 40/20 (2019.01); G01N 33/564 (2006.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); C12Q 1/6883 (2013.01); G01N 33/53 (2013.01); G01N 33/564 (2013.01); G16B 40/00 (2019.02); G16B 40/20 (2019.02); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/475 (2013.01); G01N 2333/4709 (2013.01); G01N 2333/4737 (2013.01); G01N 2333/485 (2013.01); G01N 2333/5412 (2013.01); G01N 2333/70503 (2013.01); G01N 2333/70578 (2013.01); G01N 2333/72 (2013.01); G01N 2333/96494 (2013.01); G01N 2800/102 (2013.01); G01N 2800/60 (2013.01);
Abstract

Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).


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