The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2022
Filed:
May. 17, 2019
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Neil Aronin, Newtonville, MA (US);
Phillip D. Zamore, Northboro, MA (US);
Assignee:
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/11 (2006.01); A61K 48/00 (2006.01); C07H 21/02 (2006.01); C12N 5/07 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 48/005 (2013.01); C07H 21/02 (2013.01); C12N 5/06 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/531 (2013.01); C12N 2320/30 (2013.01); C12N 2320/34 (2013.01);
Abstract
The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.