The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2022

Filed:

Nov. 01, 2017
Applicant:

Beijing Vjt Bio Co., Ltd., Beijing, CN;

Inventors:

Haoshu Luo, Beijing, CN;

Lei Shi, Beijing, CN;

Guo Han, Beijing, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/59 (2006.01); A61K 47/68 (2017.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/59 (2013.01); A61K 47/68 (2017.08); C12N 15/62 (2013.01); C12N 15/85 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

Two long-acting recombinant porcine FSH (follicle-stimulating hormone) fusion proteins, comprising pFSH-Fc-1 and pFSH-Fc-2. α subunit/β subunit is directly or indirectly fused on a Fc fragment by means of a linking component; the β subunit/α subunit is combined with the α subunit/β subunit by means of a Van der Waals force or the linking component. The porcine FSH fusion proteins can be prepared by an eukaryotic expression system based on a gene engineering technology. The two porcine FSH fusion proteins have a good medicinal effect and have a longer half-life period as compared with that of a natural porcine FSH; the two porcine FSH fusion proteins do not generate an undesirable effect on animals and can replace pregnant mare serum gonadotropin (PMSG) to be used in animal breeding production. The two porcine FSH fusion proteins can be used for preparation of medicines in the field of animal breeding.


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