The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2022
Filed:
Oct. 31, 2016
Applicant:
Crage Medical Co., Limited, Mongkok Kowloon, HK;
Inventors:
Zonghai Li, Shanghai, CN;
Zeyan Pan, Shanghai, CN;
Zhimin Shi, Shanghai, CN;
Bo Song, Shanghai, CN;
Peng Wang, Shanghai, CN;
Assignee:
CRAGE Medical Co., Limited, Mongkok Kowloon, HK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61P 35/00 (2006.01); C12N 5/10 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01); C07K 14/47 (2006.01); A61K 39/17 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/4747 (2013.01); A61K 35/17 (2013.01); A61K 39/17 (2013.01); A61P 35/00 (2018.01); C12N 5/0638 (2013.01); C12N 5/10 (2013.01); C12N 15/62 (2013.01); C12N 15/63 (2013.01);
Abstract
Provided is a chimeric antigen receptor-modified immune effector cell carrying a procedural death ligand 1 (PD-L1) blocking agent. Also provided is a method for secreting and expressing a PD-L1 blocking agent using the immune effector cell as a carrier to improve the anti-tumour effect of the chimeric antigen receptor-modified immune effector cell.