The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2022

Filed:

Jul. 23, 2015
Applicants:

Northeastern University, Boston, MA (US);

University of Florida Research Foundation, Inc., Gainesville, FL (US);

Inventors:

Ganeshsingh A. Thakur, Cambridge, MA (US);

Abhijit R. Kulkarni, Boston, MA (US);

Roger Lee Papke, Gainesville, FL (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/04 (2006.01); C07D 221/16 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 405/04 (2006.01); C07D 409/04 (2006.01); C07D 409/10 (2006.01); C07D 409/14 (2006.01); C07D 417/04 (2006.01); C07D 491/048 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); C07D 221/16 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 409/04 (2013.01); C07D 409/10 (2013.01); C07D 409/14 (2013.01); C07D 417/04 (2013.01); C07D 491/048 (2013.01);
Abstract

Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.


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