The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2022

Filed:

Jan. 05, 2021
Applicant:

Theravance Biopharma R&d Ip, Llc, South San Francisco, CA (US);

Inventors:

Paul R. Fatheree, San Francisco, CA (US);

John R. Jacobsen, San Mateo, CA (US);

Gary E. L. Brandt, Alameda, CA (US);

Melissa Fleury, Brisbane, CA (US);

Lan Jiang, Foster City, CA (US);

Cameron Smith, San Bruno, CA (US);

Steven D. E. Sullivan, San Francisco, CA (US);

Lori Jean Van Orden, San Francisco, CA (US);

Anne-Marie Beausoleil, Redwood City, CA (US);

Assignee:

Theravance Biopharma R&D IP, LLC, South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/416 (2006.01); A61P 43/00 (2006.01); A61P 11/06 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/416 (2013.01); A61K 31/437 (2013.01); A61P 11/00 (2018.01); A61P 11/06 (2018.01); A61P 43/00 (2018.01);
Abstract

The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.


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