The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2022
Filed:
Aug. 17, 2018
Applicant:
Agilent Technologies, Inc., Santa Clara, CA (US);
Inventors:
Douglas J. Dellinger, Boulder, CO (US);
Joel Myerson, Berkeley, CA (US);
Brian Smart, Santa Clara, CA (US);
Assignee:
Agilent Technologies, Inc., Santa Clara, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 1/06 (2006.01); C07D 405/12 (2006.01); C07D 317/34 (2006.01); C07D 403/06 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); C07D 317/34 (2013.01); C07D 403/06 (2013.01); C07H 21/02 (2013.01); C07H 1/06 (2013.01);
Abstract
Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.