The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2022
Filed:
Jun. 30, 2017
Trustees of Tufts College, Medford, MA (US);
David L. Kaplan, Concord, MA (US);
Sarah Lightfoot Vidal, Woburn, MA (US);
Rosalyn Abbott, Lynnfield, MA (US);
Siwei Zhao, Waltham, MA (US);
Dana Cairns, Sommerville, MA (US);
Fiorenzo G. Omenetto, Lexington, MA (US);
Trustees of Tufts College, Medford, MA (US);
Abstract
The present invention provides, in some embodiments, multi-layer silk compositions including a first layer comprising silk fibroin and keratinocytes, a second layer comprising silk fibroin and fibroblasts, a third layer comprising silk fibroin and adipocytes, and a plurality of nervous system cells, wherein at least some of the plurality of nervous system cells span at least two layers, and methods of making and using the same. In some embodiments, provided methods and compositions further include immune cells and/or endothelial cells.