The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2022
Filed:
Oct. 17, 2018
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Marie-Pierre Collin-Kroepelin, Wuppertal, DE;
Peter Kolkhof, Wuppertal, DE;
Thomas Neubauer, Wuppertal, DE;
Chantal Fuerstner, Muelheim/Ruhr, DE;
Elisabeth Pook, Wuppertal, DE;
Matthias Beat Wittwer, Riehen, CH;
Carsten Schmeck, Muelheim, DE;
Pierre Wasnaire, Duesseldorf, DE;
Heiko Schirmer, Solingen, DE;
Hana Cernecka, Wuppertal, DE;
Karoline Droebner, Velbert, DE;
Hanna Tinel, Wuppertal, DE;
Anja Buchmueller, Essen, DE;
Thomas Mondritzki, Essen, DE;
Axel Kretschmer, Wuppertal, DE;
Klemens Lustig, Wuppertal, DE;
Robert Fricke, Cologne, DE;
Guillaume Levilain, Wuppertal, DE;
Ursula Krenz, Leichlingen, DE;
Norbert Witowski, Wolfenbuettel, DE;
Bayer Aktiengesellschaft, Leverkusen, DE;
Abstract
The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.