The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2022

Filed:

Mar. 01, 2019
Applicant:

University College Cardiff Consultants Limited, Cardiff, GB;

Inventors:

Simon Ward, Cardiff, GB;

Paul Beswick, Cambridge, GB;

Lewis Pennicott, Falmer, GB;

Tristan Reuillon, Falmer, GB;

Irina Chuckowree, Falmer, GB;

Carolina Villalonga-Barber, Falmer, GB;

Roderick Alan Porter, Falmer, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 25/28 (2006.01); A61K 31/4439 (2006.01); A61P 25/18 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/553 (2006.01); A61K 45/06 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 413/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); A61P 25/18 (2018.01); A61P 25/28 (2018.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 413/10 (2013.01);
Abstract

The invention provides compounds of the formula (I): (I) wherein A, A, R, R, B, B, X, X, n, a and b are as defined are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia.


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