The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2022
Filed:
Mar. 09, 2020
Applicant:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Inventors:
Albert Edge, Brookline, MA (US);
Judith Kempfle, Brookline, MA (US);
Dunia Abdul-Aziz, Boston, MA (US);
Assignee:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 27/16 (2006.01); A61K 31/19 (2006.01); A61K 31/137 (2006.01); A61K 38/17 (2006.01); A61K 38/12 (2006.01); A61K 9/00 (2006.01); A61K 31/165 (2006.01); A61K 31/7088 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/19 (2013.01); A61K 9/0019 (2013.01); A61K 9/0046 (2013.01); A61K 31/137 (2013.01); A61K 31/165 (2013.01); A61K 31/7088 (2013.01); A61K 38/12 (2013.01); A61K 38/1709 (2013.01); A61K 45/06 (2013.01); A61P 27/16 (2018.01);
Abstract
The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss. Such compositions and methods include modulating the epigenetic status of the cell, or rate of protein degradation, to increase expression and/or levels of Atoh1 protein.