The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2022

Filed:

Sep. 10, 2019
Applicant:

Digital Harmonic Llc, Ellicott City, MD (US);

Inventors:

Paul Reed Smith, Annapolis, MD (US);

William G. Nelson, Cockeysville, MD (US);

Shane G. W. Morris, Baltimore, MD (US);

Sandor Szalay, Baltimore, MD (US);

Jonathan B. Coulter, Baltimore, MD (US);

Frederick M. Slay, Okatie, SC (US);

Eric K. Pritchard, Berkeley Springs, WV (US);

Assignee:

Digital Harmonic LLC, Ellicott City, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); G01N 33/50 (2006.01); G01N 15/14 (2006.01); G06K 9/00 (2022.01); G01R 23/16 (2006.01); G01R 23/02 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1484 (2013.01); G01N 15/1459 (2013.01); G01R 23/02 (2013.01); G01R 23/16 (2013.01); G06K 9/0053 (2013.01); G01N 2015/1486 (2013.01); G01N 2015/1493 (2013.01);
Abstract

Disclosed are systems and methods for measuring vibrational spectra of a living cells and tissue that includes a low noise consistent optical source creating a photon beam, a support device, a photon-to-electron converter/detector outputting a streamed analog electrical signal, an analog-to-digital converter, and a digital signal processor with specialized software for measuring and characterizing the signal contained in the photon beam and its subsequent detector's streamed analog converted to digital signal. Motion of the living sample causes modulation to the photon beam as it passes through the living samples by how much of the photon beam is blocked, absorbed or deflected. In addition, specific sub-cellular vibrational features can be segregated utilizing fluorescent markers.


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