The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2022

Filed:

Oct. 08, 2019
Applicant:

Roche Sequencing Solutions, Inc., Pleasanton, CA (US);

Inventors:

Frank Bergmann, Iffeldorf, DE;

Ian Quang Chau, San Jose, CA (US);

Peter Crisalli, Mountain View, CA (US);

Hannah Marie Kallewaard-Lum, Santa Clara, CA (US);

Hannes Kuchelmeister, Munich, DE;

Sebastian Johannes Pomplun, Munich, DE;

Hasham Saqib, San Jose, CA (US);

Christian Wellner, Iffeldorf, DE;

Assignee:

Roche Sequencing Solutions, Inc., Pleasanton, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6869 (2018.01); C07D 295/13 (2006.01); C07D 487/04 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C07D 295/13 (2013.01); C07D 487/04 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); A61K 47/6807 (2017.08); C12Q 2560/00 (2013.01); C12Q 2563/107 (2013.01); C12Q 2563/113 (2013.01);
Abstract

The present invention relates to improving the processing rate of a sequencing reaction, for example in a nanopore sequencing reaction, by means of using improved nucleoside-tags. The tags are linked to the nucleoside phosphate via a Pictet Spengler reaction. Exemplary sequencing reactions that are improved by the present methods include nanopore-based nucleic acid sequencing-by-synthesis reactions.


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