The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2022
Filed:
Feb. 06, 2018
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Dennis Buckley, Jamaica Plain, MA (US);
Georg Winter, Vienna, AT;
Andrew J. Phillips, Arlington, MA (US);
Timothy Heffernan, Sugar Land, TX (US);
James Bradner, Weston, MA (US);
Justin Roberts, Cambridge, MA (US);
Behnam Nabet, Boston, MA (US);
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Abstract
The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.