The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2022
Filed:
Jun. 08, 2018
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
System Biosciences, Inc., Palo Alto, CA (US);
Kevin Chun-Kai Wang, Stanford, CA (US);
Stefanie Morgan, Palo Alto, CA (US);
Fangting Wu, San Jose, CA (US);
Chiao-Chain Huang, Los Altos, CA (US);
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US);
SYSTEM BIOSCIENCES INC., Palo Alto, CA (US);
Abstract
Chromatin looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromatin loops have been described. Disclosed herein is an engineered method for chromatin loop reorganization using CRISPR-dCas9 (CLOuD9) to selectively and reversibly establish chromatin loops. Disclosed herein is the power of this technology to selectively modulate gene expression at targeted loci.