The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2022

Filed:

Jun. 11, 2020
Applicant:

Tepha, Inc., Lexington, MA (US);

Inventors:

Dennis Connelly, Arlington, MA (US);

Fabio Felix, Foxborough, MA (US);

David P. Martin, Arlington, MA (US);

Jon Montcrieff, Mansfield, MA (US);

Said Rizk, Windham, NH (US);

Simon F. Williams, Cambridge, MA (US);

Assignee:

Tepha, Inc., Lexington, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C08J 9/12 (2006.01); A61K 47/34 (2017.01); A61L 15/26 (2006.01); A61L 15/42 (2006.01); A61L 26/00 (2006.01); A61L 27/18 (2006.01); A61L 27/56 (2006.01); A61L 31/06 (2006.01); A61L 31/14 (2006.01); C08G 63/06 (2006.01); C08L 67/04 (2006.01); A61K 9/12 (2006.01);
U.S. Cl.
CPC ...
C08J 9/122 (2013.01); A61K 9/122 (2013.01); A61K 47/34 (2013.01); A61L 15/26 (2013.01); A61L 15/425 (2013.01); A61L 26/0019 (2013.01); A61L 26/0085 (2013.01); A61L 27/18 (2013.01); A61L 27/56 (2013.01); A61L 31/06 (2013.01); A61L 31/146 (2013.01); C08G 63/06 (2013.01); C08L 67/04 (2013.01); C08J 2203/06 (2013.01); C08J 2203/08 (2013.01); C08J 2205/052 (2013.01); C08J 2207/10 (2013.01); C08J 2367/04 (2013.01); C08L 2203/02 (2013.01); C08L 2203/14 (2013.01); C08L 2205/02 (2013.01);
Abstract

Methods to produce substantially closed cell foams with densities less than 0.75 g/cm, and more preferably less than 0.5 g/cm, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm. The foam may include poly-4-hydroxybutyrate or a copolymer thereof. Preferably, the foam is derived by heating a foam polymer formula to a temperature above the melt temperature of the polymer to form a melt polymer system, adding a blowing agent to produce a foamable melt, extruding the foamable melt through a die to a lower pressure to cause foaming, cooling of the foam, and solidification of the foam. These foam structures can be used for fabrication of medical products.


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