The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2022

Filed:

Jun. 25, 2019
Applicant:

The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);

Inventors:

Jason O. Fiering, Boston, MA (US);

Kenneth T. Kotz, Newton, MA (US);

Nathan Francis Moore, Canton, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61M 1/36 (2006.01); B01L 3/00 (2006.01); B03B 1/04 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
A61M 1/3678 (2014.02); A61M 1/3693 (2013.01); B01L 3/502753 (2013.01); B01L 3/502761 (2013.01); B03B 1/04 (2013.01); A61M 2205/0244 (2013.01); B01L 2200/0652 (2013.01); B01L 2400/0436 (2013.01); G01N 2015/1081 (2013.01);
Abstract

A method for separating cells in a biofluid includes pretreating the biofluid by introducing an additive comprising a cell activator, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel to accumulate target cells in a primary stream and non-target cells in a secondary stream. A system for microfluidic cell separation capable of separating target cells from non-target cells in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive comprising a cell activator, and at least one acoustic transducer coupled to the microfluidic separation channel.


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