The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2022
Filed:
Mar. 21, 2017
Applicant:
Marengo Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Andreas Loew, Somerville, MA (US);
Brian Edward Vash, Cambridge, MA (US);
Assignee:
Marengo Therapeutics, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); C07K 16/32 (2006.01); C07K 14/55 (2006.01); C07K 14/71 (2006.01); C07K 14/705 (2006.01); C07K 14/47 (2006.01); A61K 39/00 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 38/177 (2013.01); A61K 39/0011 (2013.01); A61K 39/39558 (2013.01); C07K 14/4748 (2013.01); C07K 14/55 (2013.01); C07K 14/70596 (2013.01); C07K 14/71 (2013.01); C07K 16/2803 (2013.01); C07K 16/2809 (2013.01); C07K 16/2827 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); A61K 2039/507 (2013.01); A61K 2039/515 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/75 (2013.01);
Abstract
Multispecific molecules that include i) a tumor-targeting moiety; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.