The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2022
Filed:
Jul. 06, 2011
Andrew Geall, Littleton, MA (US);
Christian Mandi, Lexington, MA (US);
Derek O'hagan, Winchester, MA (US);
Manmohan Singh, Cary, NC (US);
Andrew Geall, Littleton, MA (US);
Christian Mandi, Lexington, MA (US);
Derek O'Hagan, Winchester, MA (US);
Manmohan Singh, Cary, NC (US);
GLAXOSMITHKLINE BIOLOGICAL SA, Rixensart, BE;
Abstract
Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.