The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 05, 2022

Filed:

Apr. 21, 2017
Applicant:

Mallinckrodt Pharmaceuticals Ireland Limited, Dublin, IE;

Inventors:

Jim Potenziano, Binghamton, NY (US);

Douglas R. Hansell, Easton, PA (US);

Jeff Griebel, Arora, CO (US);

Eddie Costa, San Diego, CA (US);

Lisa Cooper, Upper Black Eddy, PA (US);

David William Newman, Lebanon, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 1/02 (2006.01); C12N 5/078 (2010.01); A61M 1/14 (2006.01); A61L 15/16 (2006.01); A61P 43/00 (2006.01); A61K 33/06 (2006.01); A61K 33/24 (2019.01); A61P 9/08 (2006.01); A61K 31/74 (2006.01); C12N 5/00 (2006.01); A61P 9/10 (2006.01); A61P 7/02 (2006.01); A61M 15/00 (2006.01); A61M 16/00 (2006.01);
U.S. Cl.
CPC ...
A01N 1/0226 (2013.01); A01N 1/0247 (2013.01); C12N 5/0641 (2013.01); A01N 1/02 (2013.01); A61K 31/74 (2013.01); A61K 33/06 (2013.01); A61K 33/24 (2013.01); A61L 15/16 (2013.01); A61M 1/14 (2013.01); A61M 15/00 (2013.01); A61M 16/00 (2013.01); A61P 7/02 (2018.01); A61P 9/08 (2018.01); A61P 9/10 (2018.01); A61P 43/00 (2018.01); C12N 5/00 (2013.01);
Abstract

Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.


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