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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11286492 B1

PDFFull Text
Date of Patent:
Mar. 29, 2022

Filed:

Aug. 20, 2021

Artificial nucleic acid molecules for improved protein expression

Applicant:

Curevac Ag, Tübingen, DE;

Inventors:

Andreas Thess, Kusterdingen, DE;

Thomas Schlake, Gundelfingen, DE;

Stefanie Grund, Stuttgart, DE;

Assignee:

CureVac AG, Tübingen, DE;

Attorney:

Parker Highlander PLLC

Primary Examiner:

Channing S Mahatan

Int. Cl.
CPC ...
C12N 15/67 (2006.01); C12N 15/68 (2006.01); C12N 15/85 (2006.01); A61K 39/145 (2006.01); A61K 39/12 (2006.01); A61K 39/205 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/67 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 39/205 (2013.01); C12N 15/68 (2013.01); C12N 15/85 (2013.01); A61K 48/00 (2013.01); A61K 2039/53 (2013.01); A61K 2039/54 (2013.01); A61K 2039/575 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16171 (2013.01); C12N 2760/20134 (2013.01); C12N 2760/20171 (2013.01); C12N 2830/50 (2013.01);
Abstract

The invention relates to an artificial nucleic acid molecule comprising an open reading frame and a 3'-UTR comprising at least one poly(A) sequence or a polyadenylation signal. The invention further relates to a vector comprising the artificial nucleic acid molecule comprising an open reading frame and a 3′-UTR comprising at least one poly(A) sequence or a polyadenylation signal, to a cell comprising the artificial nucleic acid molecule or the vector, to a pharmaceutical composition comprising the artificial nucleic acid molecule or the vector and to a kit comprising the artificial nucleic acid molecule, the vector and/or the pharmaceutical composition. The invention also relates to a method for increasing protein production from an artificial nucleic acid molecule and to the use of a 3′-UTR for a method for increasing protein production from an artificial nucleic acid molecule. Moreover, the invention concerns the use of the artificial nucleic acid molecule, the vector, the kit or the pharmaceutical composition as a medicament, as a vaccine or in gene therapy.

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