The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2022
Filed:
Mar. 19, 2019
Applicant:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Inventors:
Albert Edge, Brookline, MA (US);
Yen-Fu Cheng, Boston, MA (US);
Judith Kempfle, Brookline, MA (US);
Dunia Abdul-Aziz, Boston, MA (US);
Assignee:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); C12N 15/113 (2010.01); A61K 38/12 (2006.01); A61K 31/69 (2006.01); A61K 38/15 (2006.01); A61K 45/06 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 9/00 (2006.01); A61K 31/407 (2006.01); A61K 38/05 (2006.01); A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 9/0046 (2013.01); A61K 31/407 (2013.01); A61K 31/69 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); A61K 38/07 (2013.01); A61K 38/12 (2013.01); A61K 38/15 (2013.01); A61K 38/1709 (2013.01); A61K 45/06 (2013.01); A61K 48/0075 (2013.01); C07K 14/47 (2013.01); C12N 15/113 (2013.01); C12Y 603/02019 (2013.01); A61K 38/00 (2013.01); C12N 2310/14 (2013.01);
Abstract
The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss by modulating the rate of Atoh1 protein degradation to increase levels of Atoh1 protein.