The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2022
Filed:
Apr. 03, 2020
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Peter Hagedorn, Horsholm, DK;
Dennis Jul Hansen, Farum, DK;
Heidi Rye Hudlebusch, Brønshøj, DK;
Lykke Pedersen, Copenhagen NV, DK;
Søren Vestergaard Rasmussen, Espergærde, DK;
Mette Ladefoged, Birkerød, DK;
HOFFMANN-LA ROCHE INC., Little Falls, NJ (US);
Abstract
The present invention relates to antisense oligonucleotides that are capable of modulating expression of ATXN2 in a target cell. The oligonucleotides hybridize to ATXN2 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of neurodegenerative diseases such as spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), Alzheimer's frontotemporal dementia (FTD), parkinsonism and conditions with TDP-43 proteinopathies using the oligonucleotide.