The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2022

Filed:

Sep. 28, 2017
Applicants:

Syngenta Participations Ag, Basel, CH;

Devgen NV, Ghent, BE;

Inventors:

Pascale Feldmann, Ghent, BE;

Jeffrey David Fowler, Greensboro, NC (US);

Nema Devi Jhurry, Greensboro, NC (US);

Isabelle Maillet, Ghent, BE;

Marta Omedes Pujol, Berkshire, GB;

Assignees:

SYNGENTA PARTICIPATIONS AG, Basel, CH;

Devgen NV, Ghent, BE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/10 (2006.01); A01N 63/60 (2020.01);
U.S. Cl.
CPC ...
C12N 15/1003 (2013.01); A01N 63/60 (2020.01); C12N 15/111 (2013.01); C12N 2320/51 (2013.01);
Abstract

Methods of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the cell composition a compound having the function of a protein—or amine—cross linking agent and/or an acid, and compositions comprising the cells comprising dsRNA, and protein cross linking agents and/or acids, as well as the use of the cross linking agents and/or acids in the method.


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