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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11286285 B1

PDFFull Text
Date of Patent:
Mar. 29, 2022

Filed:

Feb. 18, 2015

Modified biotin, streptavidin mutant, and usage of them

Applicant:

Savid Therapeutics Inc., Tokyo, JP;

Inventors:

Akira Sugiyama, Tokyo, JP;

Hirofumi Doi, Tokyo, JP;

Tatsuhiko Kodama, Tokyo, JP;

Tsuyoshi Inoue, Osaka, JP;

Eiichi Mizohata, Osaka, JP;

Tatsuya Kawato, Osaka, JP;

Tomohiro Meshizuka, Osaka, JP;

Motomu Kanai, Tokyo, JP;

Yohei Shimizu, Tokyo, JP;

Noriaki Takasu, Tokyo, JP;

Mari Takatsu, Tokyo, JP;

Assignee:

SAVID THERAPEUTICS INC., Tokyo, JP;

Attorney:

Greenblum & Bernstein, P.L.C.

Primary Examiner:

Frederick F Krass

Assistant Examiner:

Melissa J Perreira

Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); C07K 14/36 (2006.01); A61K 49/00 (2006.01); C07D 519/00 (2006.01); C07D 495/04 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C09B 23/10 (2006.01); C07K 14/00 (2006.01); A61K 49/10 (2006.01);
U.S. Cl.
CPC ...
C07K 14/36 (2013.01); A61K 49/0032 (2013.01); A61K 49/0052 (2013.01); A61K 49/0058 (2013.01); C07D 495/04 (2013.01); C07D 519/00 (2013.01); C07K 16/22 (2013.01); C07K 16/2887 (2013.01); C09B 23/107 (2013.01); A61K 49/106 (2013.01); C07K 14/00 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2319/21 (2013.01); C07K 2319/22 (2013.01); C07K 2319/33 (2013.01);
Abstract

An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.

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