The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2022
Filed:
Dec. 19, 2018
Applicant:
Glaxosmithkline Biologicals SA, Rixensart, BE;
Inventors:
Martin Braun, Schlieren, CH;
Amirreza Faridmoayer, Schlieren, CH;
Sabina Marietta Gerber, Schlieren, CH;
Markus Mueller, Schlieren, CH;
Assignee:
GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07K 14/31 (2006.01); A61K 47/64 (2017.01); A61K 39/085 (2006.01); C12N 9/10 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/31 (2013.01); A61K 39/085 (2013.01); A61K 47/6425 (2017.08); C12N 9/1051 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention discloses modifiedHIa proteins which show reduced tendency to aggregate, improving protein stability and yield. Said modified HIa proteins optionally also contain glycosylation site consensus sequences. The invention also discloses a conjugate comprising a modified HIa protein and an antigen (for example asaccharide antigen), wherein the antigen is linked to an amino acid residue of the modified HIa protein.