The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2022
Filed:
Nov. 15, 2018
The Broad Institute, Inc., Cambridge, MA (US);
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Steven James Ferrara, Cambridge, MA (US);
Michael H. Serrano-Wu, Cambridge, MA (US);
Chris Lemke, Cambridge, MA (US);
David McKinney, Cambridge, MA (US);
Mark Fitzgerald, Cambridge, MA (US);
Christopher Nasveschuk, Cambridge, MA (US);
Kiel Lazarski, Cambridge, MA (US);
Laura Furst, Cambridge, MA (US);
Guo Wei, Cambridge, MA (US);
Patrick Ryan McCarren, Cambridge, MA (US);
Kai Thede, Leverkusen, DE;
Anne Mengel, Leverkusen, DE;
Clara Christ, Leverkusen, DE;
Joachim Kuhnke, Leverkusen, DE;
Sarah Anna Liesa Johannes, Leverkusen, DE;
Philipp Buchgraber, Leverkusen, DE;
Ulrich Klar, Leverkusen, DE;
Ulrike Sack, Leverkusen, DE;
Stefan Kaulfuss, Leverkusen, DE;
Amaury Ernesto Fernandez-Montalvan, Leverkusen, DE;
Nicolas Werbeck, Leverkusen, DE;
Ursula Mönning, Leverkusen, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Bayer Aktiengesellschaft, Leverkusen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Abstract
The present invention relates to macrocyclic indole derivatives of general formula (I): in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.