The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2022

Filed:

Feb. 18, 2015
Applicant:

Cytiva Bioprocess R&d Ab, Uppsala, SE;

Inventors:

Jean-Luc Maloisel, Uppsala, SE;

Karolina Busson, Uppsala, SE;

Karol Lacki, Uppsala, SE;

Bjorn Noren, Uppsala, SE;

Helena Skoglar, Uppsala, SE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01D 15/12 (2006.01); B01D 15/20 (2006.01); B01D 15/30 (2006.01); B01D 15/36 (2006.01); B01J 20/28 (2006.01); B01J 20/286 (2006.01); B01J 20/32 (2006.01); C07K 1/22 (2006.01); C07K 14/765 (2006.01); C07K 14/77 (2006.01); C12N 1/20 (2006.01);
U.S. Cl.
CPC ...
B01J 20/3293 (2013.01); B01D 15/125 (2013.01); B01D 15/203 (2013.01); B01D 15/305 (2013.01); B01D 15/363 (2013.01); B01J 20/286 (2013.01); B01J 20/28019 (2013.01); B01J 20/327 (2013.01); B01J 20/3212 (2013.01); B01J 20/3219 (2013.01); B01J 20/3248 (2013.01); B01J 20/3278 (2013.01); C07K 1/22 (2013.01); C07K 14/765 (2013.01); C07K 14/77 (2013.01); C12N 1/20 (2013.01);
Abstract

The invention discloses a separation matrix for purification of biological particles, comprising a plurality of particles having a porous core entity and a porous shell entity covering the core entity, wherein the core entity comprises at least 50 micromole/ml primary amines present on covalently attached ligands displaying at least two primary amines per ligand and the shell entity comprises less than 20 micromole/ml primary amines The invention further discloses a method of purifying biological particles and a method of manufacturing a separation matrix.


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