The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2022

Filed:

Apr. 01, 2015
Applicant:

Yale University, New Haven, CT (US);

Inventors:

Tarek Fahmy, Middlefield, CT (US);

Albert Sinusas, Guilford, CT (US);

Jung Seok Lee, New Haven, CT (US);

Dongin Kim, Glastonbury, CT (US);

Anthony Mathur, London, GB;

John Martin, London, GB;

Assignee:

YALE UNIVERSITY, New Haven, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 41/00 (2020.01); A61N 2/00 (2006.01); A61N 2/06 (2006.01); A61K 35/44 (2015.01); A61K 35/545 (2015.01); A61L 27/02 (2006.01); A61L 27/04 (2006.01); A61L 27/06 (2006.01); A61L 27/18 (2006.01); A61L 27/30 (2006.01); A61L 27/34 (2006.01); A61L 27/58 (2006.01); A61L 31/02 (2006.01); A61L 31/06 (2006.01); A61L 31/08 (2006.01); A61L 31/10 (2006.01); A61L 31/14 (2006.01); A61F 2/82 (2013.01);
U.S. Cl.
CPC ...
A61K 41/0052 (2013.01); A61K 35/44 (2013.01); A61K 35/545 (2013.01); A61L 27/025 (2013.01); A61L 27/042 (2013.01); A61L 27/047 (2013.01); A61L 27/06 (2013.01); A61L 27/18 (2013.01); A61L 27/306 (2013.01); A61L 27/34 (2013.01); A61L 27/58 (2013.01); A61L 31/022 (2013.01); A61L 31/028 (2013.01); A61L 31/06 (2013.01); A61L 31/088 (2013.01); A61L 31/10 (2013.01); A61L 31/148 (2013.01); A61N 2/002 (2013.01); A61N 2/06 (2013.01); A61F 2/82 (2013.01); A61F 2210/009 (2013.01); A61F 2210/0076 (2013.01); A61L 2400/18 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01); A61L 2420/08 (2013.01); A61L 2430/20 (2013.01);
Abstract

It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a 'Super Conducting Quantum Interference Device', which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.


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