The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2022
Filed:
Sep. 27, 2016
Applicant:
National University Corporation Chiba University, Chiba, JP;
Inventors:
Hideo Iba, Chiba, JP;
Takeshi Haraguchi, Chiba, JP;
Assignee:
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, Chiba, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 45/00 (2013.01); A61K 45/06 (2013.01); A61K 48/00 (2013.01); A61P 35/00 (2018.01);
Abstract
Tumor growth was found to be significantly suppressed in vivo by inhibiting both miRNA containing 5'-AACACUG-3′ as a seed sequence and miRNA containing 5′-AAUACUG-3′ as a seed sequence. The inhibition significantly altered the proportion of subpopulations of tumor cells and reduced the tumorigenicity in all subpopulations. The inhibition also exerted a remarkable tumor-shrinking effect on already-formed tumors. The present invention provides novel therapeutic potential against tumor.