The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2022
Filed:
Aug. 03, 2017
The Broad Institute, Inc., Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Thomas Sundberg, Cambridge, MA (US);
Alykhan Shamji, Cambridge, MA (US);
Ramnik Xavier, Boston, MA (US);
Liv Johannessen, Boston, MA (US);
Nathanael Gray, Boston, MA (US);
Bernard Khor, Boston, MA (US);
Jose Perez, Cambridge, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
A method for treating inflammation and/or autoimmune diseases comprises administering to a subject in need thereof, a composition comprising a CDK8 inhibitor. In another aspect, a method for increasing IL-10 production comprises administering to a subject in need thereof a CDK8 inhibitor. In another aspect, a method for enhancing Tcell differentiation, comprising administering a composition comprising a CDK8 inhibitor. In certain example embodiments, the subject suffers from an inflammatory bowel disease. In certain other example embodiments, the subject requires immunosuppression to prevent rejection following a transplantation procedure.