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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11285135 B1

PDFFull Text
Date of Patent:
Mar. 29, 2022

Filed:

Nov. 05, 2019

Kras g12c inhibitors and methods of using the same

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Brian Alan Lanman, Woodland Hills, CA (US);

Victor J. Cee, Thousand Oaks, CA (US);

Alexander J. Pickrell, Westlake Village, CA (US);

Anthony B. Reed, Newbury Park, CA (US);

Kevin C. Yang, San Gabriel, CA (US);

David John Kopecky, Washington, DC (US);

Hui-Ling Wang, Thousand Oaks, CA (US);

Patricia Lopez, Woodland Hills, CA (US);

Kate Ashton, Westlake Village, CA (US);

Shon Booker, Sherman Oaks, CA (US);

Christopher M. Tegley, Thousand Oaks, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:

Markus Bergauer

Primary Examiner:

Brian E McDowell

Int. Cl.
CPC ...
C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 513/04 (2006.01); A61K 31/428 (2006.01); A61K 31/496 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01); A61K 31/5025 (2006.01); A61K 31/502 (2006.01); A61K 31/517 (2006.01); C07D 275/04 (2006.01); C07D 471/08 (2006.01); C07D 403/04 (2006.01); C07D 401/04 (2006.01); C07D 487/04 (2006.01); C07D 239/80 (2006.01); C07D 487/10 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/428 (2013.01); A61K 31/496 (2013.01); A61K 31/502 (2013.01); A61K 31/5025 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61P 35/00 (2018.01); C07D 239/80 (2013.01); C07D 275/04 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 513/04 (2013.01);
Abstract

Provided herein are methods of treating cancer with KRAS G12C inhibitors of Formula I and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

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