The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2022

Filed:

Oct. 26, 2016
Applicants:

Agency for Science, Technology and Research, Singapore, SG;

Massey University, Palmerston North, NZ;

Agresearch, Hamilton, NZ;

Inventors:

Harjinder Singh, Palmerston North, NZ;

Brendan Haigh, Hamilton, NZ;

Nicole Roy, Palmerston North, NZ;

Maxim Kiryukhin, Singapore, SG;

Maria Antipina, Singapore, SG;

Marina Novoselova, Singapore, SG;

Gleb Sukhorukov, London, GB;

Assignees:

AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, Singapore, SG;

MASSEY UNIVERSITY, Palmerston North, NZ;

AGRESEARCH, Hamilton, NZ;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/48 (2006.01); A61K 47/38 (2006.01); A61K 47/42 (2017.01); A61K 47/44 (2017.01); A61K 9/50 (2006.01); A61K 47/34 (2017.01); A61K 9/19 (2006.01);
U.S. Cl.
CPC ...
A61K 9/4825 (2013.01); A61K 9/4833 (2013.01); A61K 9/4891 (2013.01); A61K 9/5073 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01); A61K 47/42 (2013.01); A61K 9/19 (2013.01);
Abstract

Disclosed herein is a core-shell composite material comprising: a core optionally comprising an active ingredient compound; a shell structure comprising at least two alternating layers; the alternating layers being a protein layer and a polyphenol layer; and optionally a polyelectrolyte layer interfacing said core and said shell structure, said polyelectrolyte layer being disposed adjacent to said protein layer or said polyphenol layer, wherein said shell structure is selected to be resistant to degradation under gastric conditions but is degradable by one or more intestinal enzymes. In a preferred embodiment the protein is bovine serum albumin (BSA) or pepsin, the polyphenol layer is tannin or tannic acid, and the shell structure is degradable by pepsin.


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