The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2022

Filed:

Apr. 15, 2019
Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

C. Shad Thaxton, Chicago, IL (US);

Chad A. Mirkin, Wilmette, IL (US);

Kaylin M. McMahon, Chicago, IL (US);

Sushant Tripathy, Evanston, IL (US);

Raja Kannan Mutharasan, Chicago, IL (US);

David M. Leander, St. Louis, MO (US);

Andrea Luthi, Evanston, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 31/7088 (2006.01); B82Y 5/00 (2011.01); C12N 15/87 (2006.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61K 9/51 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 9/127 (2013.01); A61K 9/1271 (2013.01); A61K 9/5115 (2013.01); A61K 9/5123 (2013.01); A61K 31/7088 (2013.01); A61K 47/544 (2017.08); A61K 47/554 (2017.08); A61K 47/6917 (2017.08); A61K 47/6923 (2017.08); B82Y 5/00 (2013.01); C12N 15/87 (2013.01); C12N 15/111 (2013.01); C12N 2310/113 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01);
Abstract

Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.


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