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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11279922 B1

PDFFull Text
Date of Patent:
Mar. 22, 2022

Filed:

Feb. 22, 2019

Delivery of therapeutic agents by a collagen binding protein

Applicants:

The Board of Trustees of the University of Arkansas, Little Rock, AR (US);

The Kitasato Institute, Tokyo, JP;

Montefiore Medical Center, New York, NY (US);

National University Corporation Kagawa University, Kagawa, JP;

Inventors:

Tulasi Ponnapakkam, New York, NY (US);

Sagaya Theresa Leena Philominathan, Cheshire, CT (US);

Joshua Sakon, Fayetteville, AR (US);

Ranjitha Katikaneni, New York, NY (US);

Takaki Koide, Tokyo, JP;

Osamu Matsushita, Kanagawa, JP;

Robert C. Gensure, New York, NY (US);

Nozomu Nishi, Kagawa, JP;

Assignees:

The Board of Trustees of the University of Arkansas, Little Rock, AR (US);

The Kitasato Institute, Tokyo, JP;

Montefiore Medical Center, New York, NY (US);

National University Corporation Kagawa University, Kagawa, JP;

Attorney:

Quarles & Brady LLP

Primary Examiner:

Nita M Minnifield

Int. Cl.
CPC ...
A61K 38/29 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); C12N 9/52 (2006.01); A61K 8/49 (2006.01); A61K 8/65 (2006.01); A61Q 7/00 (2006.01); A61K 47/64 (2017.01); A61K 8/64 (2006.01); A61K 8/66 (2006.01); A61K 38/30 (2006.01); A61K 39/44 (2006.01); A61Q 7/02 (2006.01); A61K 38/27 (2006.01); C07K 14/475 (2006.01); C07K 14/485 (2006.01); C07K 14/49 (2006.01); C07K 14/495 (2006.01); C07K 14/50 (2006.01); C07K 14/51 (2006.01); C07K 14/535 (2006.01); C07K 14/61 (2006.01); C07K 14/71 (2006.01); C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); A61K 8/4913 (2013.01); A61K 8/64 (2013.01); A61K 8/65 (2013.01); A61K 8/66 (2013.01); A61K 38/179 (2013.01); A61K 38/18 (2013.01); A61K 38/1808 (2013.01); A61K 38/1825 (2013.01); A61K 38/1841 (2013.01); A61K 38/1858 (2013.01); A61K 38/1866 (2013.01); A61K 38/1875 (2013.01); A61K 38/193 (2013.01); A61K 38/27 (2013.01); A61K 38/29 (2013.01); A61K 38/30 (2013.01); A61K 39/3955 (2013.01); A61K 39/44 (2013.01); A61K 47/64 (2017.08); A61Q 7/00 (2013.01); A61Q 7/02 (2013.01); C07K 14/475 (2013.01); C07K 14/485 (2013.01); C07K 14/49 (2013.01); C07K 14/495 (2013.01); C07K 14/50 (2013.01); C07K 14/51 (2013.01); C07K 14/535 (2013.01); C07K 14/61 (2013.01); C07K 14/71 (2013.01); C07K 16/18 (2013.01); C12Y 304/24003 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/6031 (2013.01); A61K 2800/57 (2013.01); C07K 2319/31 (2013.01); C07K 2319/70 (2013.01); C07K 2319/74 (2013.01);
Abstract

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

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