The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2022
Filed:
Feb. 27, 2015
Applicant:
Merus N.v., Utrecht, NL;
Inventors:
Cecilia Anna Wilhelmina Geuijen, Utrecht, NL;
Cornelis Adriaan De Kruif, Utrecht, NL;
Mark Throsby, Utrecht, NL;
Ton Logtenberg, Utrecht, NL;
Alexander Berthold Hendrik Bakker, Utrecht, NL;
Assignee:
Merus N.V., Utrecht, NL;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/32 (2006.01); A61K 31/185 (2006.01); A61K 31/337 (2006.01); A61K 31/436 (2006.01); A61K 31/4375 (2006.01); A61K 31/4439 (2006.01); A61K 31/519 (2006.01); A61K 39/395 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61K 31/185 (2013.01); A61K 31/337 (2013.01); A61K 31/436 (2013.01); A61K 31/4375 (2013.01); A61K 31/4439 (2013.01); A61K 31/519 (2013.01); A61K 39/39558 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/526 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
The invention relates among others to antibodies comprising a first antigen-binding site that binds Erb B-2 and a second antigen-binding site that binds Erb B-3. The antibodies can typically reduce a ligand-induced receptor function of Erb B-3 on a Erb B-2 and Erb B-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an Erb B-2, Erb B-3 or Erb B-2/3 positive tumor.