The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2022
Filed:
Sep. 25, 2019
Bristol-myers Squibb Company, Princeton, NJ (US);
Jonathan Davis, Madison, WI (US);
Dasa Lipovsek, Pepperell, MA (US);
Ray Camphausen, Wayland, MA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Fibronectin type III (Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternativeFn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describesFn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided areFn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.