The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2022
Filed:
Sep. 18, 2019
Applicant:
Csl Limited, Parkville, AU;
Inventors:
Yvonne Vucica, Bern, CH;
Gary Lee Warren, Bourbonnais, IL (US);
Assignee:
CSL LIMITED, Parkville, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/775 (2006.01); C07K 1/30 (2006.01); A61K 38/17 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/775 (2013.01); C07K 1/30 (2013.01); A61K 38/00 (2013.01); A61K 38/17 (2013.01);
Abstract
The present invention relates to processes of obtaining Apo A-1 from an Apo A-1 containing protein fraction (A), comprising suspending—the Apo A-1 containing protein fraction (A) in a buffer solution (B), removing impurities from the suspension while keeping the Apo A-1 proteins solubilized, followed by precipitating Apo A˜I from the suspension and collecting the Apo A-1 precipitate. Apo A-I obtained by such processes, reconstituted HDL obtained from such Apo A-1, and pharmaceutical compositions comprising such Apo A-I and/or reconstituted HDL also are provided.