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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11279703 B1

PDFFull Text
Date of Patent:
Mar. 22, 2022

Filed:

Dec. 01, 2017

Fused pyrimidine compounds as brd4 and jak2 dual inhibitors and methods for use thereof

Applicant:

Aptose Biosciences Inc., Mississauga, CA;

Inventors:

Ram Shankar Upadhayaya, Journalist Colony, IN;

Raghava Kethiri, Bangalore, IN;

Sachin Madan, Haryana, IN;

Santosh Kumar Kotturi Rajaiah, Secunderabad, IN;

Assignee:

APTOSE BIOSCIENCES INC., Mississauga, CA;

Attorneys:

Entralta

James F. Fleming

Peter D. Weinstein

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61P 35/02 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/10 (2006.01); C07D 417/10 (2006.01); C07D 471/04 (2006.01); C07D 471/18 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 495/14 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61P 35/02 (2018.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/10 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01); C07D 471/18 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 495/14 (2013.01); C07D 519/00 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention relates to fused pyrimidine compounds, particularly pyrrolopyrimidine and thienopyrimidine compounds and derivatives thereof, pharmaceutical compositions thereof, and methods of inhibiting BRD4 and/or JAK2, as well as methods of treating various diseases and conditions, such as cancer and leukemia, with such compounds. Bromodomain binding and JAK activity are included.

Find Patent Forward Citations

Upadhayaya, Ram. (2022). Fused pyrimidine compounds as brd4 and jak2 dual inhibitors and methods for use thereof (U.S. Patent No. 11279703). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11279703

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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