The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 22, 2022

Filed:

Sep. 02, 2020
Applicant:

Zhengzhou University, Zhengzhou, CN;

Inventors:

Guifu Dai, Zhengzhou, CN;

Di Wu, Zhengzhou, CN;

Haiwei Xu, Zhengzhou, CN;

Jiazhen Zhu, Zhengzhou, CN;

Zibo Fu, Zhengzhou, CN;

Zhenzhen Guan, Zhengzhou, CN;

Xiaopei Zhang, Zhengzhou, CN;

Ning Shang, Zhengzhou, CN;

Shuqiu Zhang, Zhengzhou, CN;

Guangming Yan, Zhengzhou, CN;

Assignee:

ZHENGZHOU UNIVERSITY, Zhengzhou, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 407/04 (2006.01); C07D 307/58 (2006.01); A61P 1/16 (2006.01); A61P 13/12 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
C07D 407/04 (2013.01); A61P 1/16 (2018.01); A61P 11/00 (2018.01); A61P 13/12 (2018.01); C07D 307/58 (2013.01);
Abstract

A compound represented by formula I or II. Rand Rare at each occurrence selected from the group consisting of hydrogen, methyl, phenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 2-fluorophenyl, 2-chlorophenyl, 2-bromophenyl, 3-fluorophenyl, 3-chlorophenyl, 3-bromophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 2-fluoro-3-methoxyphenyl, 3-methoxy-4-chlorophenyl, 2,4-difluorophenyl, 2,4-dichlorophenyl, 2,4-dibromophenyl, 2-fluoro-4-chlorophenyl, 2-bromo-4-chlorophenyl, 3-fluoro-4-chlorophenyl, 3-bromo-4-chlorophenyl, 3,4-difluorophenyl, 3,4-dichlorophenyl, 3,4-dibromophenyl, 2-chloro-4-fluorophenyl, 2-bromo-4-fluorophenyl, 3-chloro-4-fluorophenyl, 3-bromo-4-fluorophenyl, 2-fluoro-4-bromophenyl, 2-chloro-4-bromobenzene group, 3-fluoro-4-bromophenyl, 3-chloro-4-bromophenyl, 2,3,4-trichlorophenyl, 2-methoxy-4-chlorophenyl, 2-hydroxy-4-chlorophenyl, 2-hydroxy-4-methoxyphenyl, 3-fluoro-4-(4-methylpiperazinyl)phenyl, 4-(N,N-dimethylamino)phenyl, and 3-fluoro-4-(4-morpholinyl)phenyl. Rand Rare hydrogen, or Rand Rare at each occurrence selected from the group consisting of —CHCHCOOH, —CHCHCHCHCOOH, —CHCH═CHCHCOOH, and —CHCHCHCHCHCHCHCOOH; or Rand Rare —COR, and Ris selected from the group consisting of 3-pyridyl, —CHCHCOOH, —CHCHCHCHCOOH, —CHCH═CHCHCOOH, and —CHCHCHCHCHCHCHCOOH.


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