The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2022
Filed:
Nov. 12, 2019
Applicant:
Immunogen, Inc., Waltham, MA (US);
Inventor:
Elizabeth Bartlett, Charlemont, MA (US);
Assignee:
IMMUNOGEN, INC., Waltham, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 47/18 (2017.01); A61K 31/5517 (2006.01); A61K 47/26 (2006.01); A61K 47/68 (2017.01); C07D 519/00 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 9/0019 (2013.01); A61K 31/5517 (2013.01); A61K 39/39591 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/186 (2013.01); A61K 47/26 (2013.01); A61K 47/6849 (2017.08); C07D 519/00 (2013.01); C07K 16/28 (2013.01); C07K 16/2803 (2013.01); C07K 16/2866 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01);
Abstract
This disclosure is directed to antibody-drug conjugates. More specifically, this disclosure is directed to compositions comprising (i) antibody-drug conjugates comprising benzodiazepines, and (ii) a small hydrophobic molecule, methods of treatment using the compositions, and methods of formulating the compositions. Furthermore, this disclosure is directed to methods of reducing reversible self-association in antibodies and in antibody-drug conjugates.