The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2022
Filed:
Apr. 16, 2015
Applicant:
Juno Therapeutics Gmbh, Munich, DE;
Inventors:
Lothar Germeroth, Munich, DE;
Christian Stemberger, Holzkirchen, DE;
Assignee:
Juno Therapeutics GmbH, Munich, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/36 (2006.01); C07K 14/195 (2006.01); C12N 5/0783 (2010.01); C12M 1/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); C12M 47/02 (2013.01); C12M 47/12 (2013.01);
Abstract
The present invention relates to in vitro-methods of expanding a population of cells such as lymphocytes, comprising contacting a sample comprising a population of cells with a multimerization reagent. The multimerization reagent has reversibly immobilized thereon (bound thereto) a first agent that provides a primary activation signal to the cells and optionally, a second agent that provides a co-stimulatory signal. The invention also provides multimerization reagents, kits, arrangements and an apparatus for expanding cells.